Slide 1:
Introduction
Slide 2:
Lactation capacity of gerbils
Slide 3:
Development of the mouse mammary gland: whole mounts
Slide 4:
Development of the mouse mammary gland: histology
Slide 5:
Alveolar Development: a diagram
Slide 6:
Genes mediating mammary development
Slide 7:
Diagram of an alveolus
Slide 8:
Mouse milk proteins
Slide 9:
Activation of milk protein genes
Slide 10:
developmental and hormonal regulation of mammary-specific genes (WAP and b-casein)
Slide 11:
Prolactin signaling: the JAK-STAT pathway
Slide 12:
Prolactin signaling: the JAK-STAT and MAPK pathways
Slide 13:
Stat5a and Stat5b are highly conserved
Slide 14:
Developmental and hormonal regulation of Stat5a and Stat5b
Slide 15:
Transient and mosaic differentiation of mammary epithelial cells: the experiment
Slide 16:
Transient and mosaic differentiation of mammary epithelial cells: the model
Slide 17:
Stat5 activity coincides mammary epithelial cell differentiation - estrus
Slide 18:
Stat5 activity coincides mammary epithelial cell differentiation - involution
Slide 19:
Who signals through Stat5 - devastation or redundancy of a gene deletion?
Slide 20
impaired mammopoiesis in Stat5a -/- mice: whole mount
Slide 21
impaired mammopoiesis in Stat5a -/- mice: histology
Slide 22
Activity of Stat5b in Stat5a -/- mice is reduced
Slide 23:
Stat5a controls proliferation and differentiation - a diagram
Slide 24:
impaired mammopoiesis in PRLR -/- mice