| Cooperating Gene | Nature of Gene | Site of Expression | Tumor Type(s) | Synergy with p53-/-? | Synergy with p53+/-? | Novel tumors | References |
| Rb | knockout | global | pituitary, adenomas | yes | yes | yes, islet cells, pinealoblastomas | 9, 10 |
| mutant p53 | transgene | global | lymphomas, lungtumors, osteosarcomas | no | yes | no | 14 |
| myc (1) | transgene | mammary gland | mammary tumors | ND | no | no | 12 |
| myc (2) | transgene | T-cells | lymphomas | yes | yes | no | 13 |
| bcl-2 | transgene | B-cells | lymphomas | no | ND | no | 11 |
| mdm-2 | knockout | global | none | no | in progress | no | 15 |
| SCID | natural mutation | lymphoid cells | lymphomas | yes | ? | no | 16 |
| APC | chemically induced mutation | global | intestinal tumors | no | no | yes, desmoid and pancreatic tumors | 17,18 |
| Wnt-1 | transgene | mammary gland | mammary tumors | yes | no | no | 19 |
| NF-1 | knockout | global | pheochromocytomas, myeloid leukemia | ? | yes | yes, rhabdomyosarcomas | 16 |
Last Update: 4/16/96
Name: Larry Donehower