Summary
The effect of insulin-like growth factor II (IGF-II) on tumour development in the mouse
mammary gland was studied. To promote extra IGF-II expression in the mammary gland, sheep
beta-lactoglobulin regulatory elements were attached to the coding regions of the mouse
Igf-2 gene and injected into the pronuclei of mouse zygotes. Mammary tumours developed in
each of the four independent lines of mice which expressed transgene IGF-II in the gland.
Tumours from two of the lines grew after transplantation to both male and female hosts.
Primary tumours contained stromal and epithelial regions, but the tumours were dominated
by mammary adenocarcinoma after transplantation. The tumours expressed high levels of
Igf-2 mRNA transcribed from the integrated transgenes.
Citation
MAMMARY-CANCER IN TRANSGENIC MICE EXPRESSING INSULIN-LIKE GROWTH-FACTOR-II (IGF-II). BATES
P, Fisher, R., Richardson, L., Hill, D.J. and Graham, C.F. BRITISH JOURNAL OF CANCER.
1995, 72:1189-1193