Slide 1:
Prolactin signaling: the JAK-STAT pathway
Slide 2:
Stat5a and Stat5b are highly conserved
Slide 3:
In vivo activation of Stat5a and Stat5b by prolactin
Slide 4:
Developmental and hormonal regulation of Stat5a and Stat5b
Slide 5:
Stat5a knock-out vector
Slide 6
impaired mammopoiesis in Stat5a -/- mice: whole mount
Slide 7
impaired mammopoiesis in Stat5a -/- mice: histology
Slide 8
Activity of Stat5b in Stat5a -/- mice is reduced
Slide 9:
Regulation of milk protein genes in Stat -/- mice
Slide 10:
Stat5a controls proliferation and differentiation - a diagram