Two copies of the prolactin receptor are required for normal mammary gland development

Abstract

Mice carrying a germ line mutation of the prolactin recptor gene have been produced by gene targeting in embryonic stem cells. Heterozygous females showed almost complete failure of lactation due to greatly reduced mammary gland development following their first, but not subsequent pregnancies.

Citations

Ormandy, C.J., Camus, A., Barra, J., Damotte, D., Lucas, B., Buteau, H., Edery, M., Brousse, N., Babinet, C., Binart, N. and Kelly, P.A. (1997) Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes and Dev., 11, 168 - 178.

Mouse Strains
The Stat5a mutation was established in both a C57BL6/129SvEv hybrid and 129SvEv inbreed genetic background.

Key Words

prolactin, prolactin receptor, mammary development

Contributed By

Paul Kelly
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e-mail: kelly@necker.fr