Karen1    Karen2
Karen Y. Cui
Dr. Yongzhi (Karen) Cui joined our laboratory in October of 1999 as a postdoctoral research fellow. She has received an MD from China Medical University in 1995 and her Ph.D. from the same institution in 2002. In LGP she focuses on several research projects. Most notebly Karen, along with Keiko Miyoshi and Greg Riedlinger, isolated and characterized the Stat3 and Stat5 locus and further discovered two novel proteins, LGP1 and LGP2, within this locus. Currently, Karen is applying cDNA microarray technology to a identify Stat5 taget genes. In addition, Karen, Greg and Keiko targeted the mouse Stat5 locus with loxP sites, which allows her now to inactivate Stat5 in a cell- and temporal-specific fashion.
Publications while at LGP

PubMed search

1. Cui, Y., Bierie, B., Miyoshi, K., Riedlinger, G., Shillingford, J., Morgan, F., Robinson, G.W. and Hennighausen, L. (2003) Stat5 signaling in mouse mammary development and function: haploinsufficiency, compensation and the identification of target genes. Submitted.

2. Wu, Y., Cui, Y., Miyoshi, K., Hennighausen, L., Green, J.E.and LeRoith, D. (2002) Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. Cancer Res., 62, 1030-1035.

3. Renou, J.-P., Bierie, B., Miyoshi, K., Cui, Y., Djiane, J., Reichenstein, M., Shani, M. and Hennighausen, L. (2003) Identification of genes differentially expressed in mouse mammary epithelium transformed by an activated beta-catenin. Oncogene, 29, 4594-4610.

4. Renou, J.-P., Bierie, B., Miyoshi, K., Cui, Y., Djiane, J., Reichenstein, M., Shani, M. and Hennighausen, L. (2003) Identification of genes differentially expressed in mouse mammary epithelium transformed by an activated beta-catenin. Oncogene, 29, 4594-4610.

5. Miyoshi, K., Meyer, B., Gruss, P., Cui, Y., Renou, J.-P., Morgan, F.V., Smith, G.H., Reichenstein, M., Shani, M., Hennighausen, L. and Robinson, G.W. (2002). Mammary epithelial cells are not able to undergo pregnancy-dependent differentiation in the absence of the helix-loop-helix inhibitor Id2. Mol. Endocrinol. 16:2892-2901.

6. Cui, Y., Miyoshi, K., Claudio, E., Siebenlist, U.K., Gonzalez, F.J., Flaws, J., Wagner, K.U. and Hennighausen, L. (2002). Loss of the peroxisome proliferation-activated receptor gamma (PPARgamma) does not affect mammary development and propensity for tumor formation but leads to reduced fertility. J. Biol. Chem. 277:17830-17835.

7. Cui, Y., Li, M., Walton, K.D., Sun, K., Hanover, J.A., Furth, P.A. and Hennighausen, L. (2001). The Stat3/5 locus encodes a novel endoplasmic reticulum and helicase-like proteins that are preferentially expressed in normal and neoplastic mammary tissue. Genomics 78:129-136.

8. Miyoshi, K., Cui, Y., Riedlinger, G., Robinson, P., Lehoczky, J., Zon, L., Oka, T., Dewar, K. and Hennighausen, L. (2001). Structures of the mouse and zebrafish Stat3/5 loci: Evolution from Drosophila to zebrafish to mouse. Genomics 71:150-155.