Markers for Mammary Differentiation (MMD)


Accumulation of milk protein mRNAs in mouse mammary tissue during pregnancy is differentially regulated. For example, high levels of WDNM1 RNA can be found already in early pregnancy, beta-casein accumulates at mid-pregnancy, WAP between day 14 and 16 of pregnancy and alpha-lactalbumin around parturition (see Robinson et al., 1995). The temporal activation of these genes most likely represents different stages of mammary development and differentiation.

Probes are available for the following differentiation markers:

Hybridization conditions for northern blots