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1. Transgenic Models to Study Mammary Development, Function and Cancer


The analysis of transgenic mice expressing regulatory genes in a deregulated fashion has provided information insight into the function of these genes in breast development, function and cancer. Information on such mice is provided on this page.


1.1. Growth Regulators

1.2. Cell Cycle Proteins

1.3. Matrix Proteins

1.4. Apoptosis Proteins

1.5. viral oncoproteins

1.6. Double Transgenics

1.7. Null Mice Carrying Transgenes

1.8. Tetracycline Inducible System

1.9. Cre Expressing Mice

1.10. Others

1.11. Transgenic mice with the MMTV-LTR

1.12 Transgenic mice with the WAP gene promoter

1.13 Transgenics with the -lactoglobulin promoter

1.14 Preclincal models for Mammary Carcinogenesis avaiable through the Jackson lab


1.1. Growth Regulators

1.1.1 Overexpression of Cell Surface b1,4-galactosyltransferase under the MT Promoter

1.1.2 The Classic WAP Milchlos Mouse

1.1.3 TGFb1 Expression under the WAP Promoter

1.1.4 TGFb1 Expression under the MMTV-LTR (Jackson lab)

1.1.5 TGFa Expression under the WAP Promoter

1.1.6 TGFa Expression under the MMTV-LTR (Jackson lab)

1.1.7 TGFa Expression under the MT Promoter

1.1.8 TGFa Expression under the MT Promoter (Jackson lab)

1.1.9 IGF1-DES Expression under the WAP Promoter (Baylor)

1.1.10 IGF1 Expression under the WAP Promoter (NIH)

1.1.11 IGF2 Expression under the b-lactoglobulin Promoter

1.1.12 IGFI Expression under the WAP Promoter (Jackson lab)

1.1.13 IGF Binding Protein 3 (BP3) Expression under the WAP Promoter

1.1.14 Int3 Expression under the WAP Promoter

1.1.15 Int3 Expression under the MMTV-LTR

1.1.16 int2 Expression under the MMTV-LTR

1.1.17 Wnt-1 Expression under the MMTV-LTR (Jackson lab)

1.1.18 Unactivated neu Expression under the MMTV-LTR

1.1.19 Activated neu Expression under the MMTV-LTR (I)

1.1.20 neu/cerb2 Expression under the MMTV-LTR (II)

1.1.21 myc Expression under the WAP Promoter (I)

1.1.22 myc Expression under the WAP Promoter (II)

1.1.23 myc Expression under the MMTV-LTR

1.1.24 ras Expression under the WAP Promoter (I)

1.1.25 ras Expression under the WAP Promoter (Jackson lab)

1.1.26 ras Expression under the MMTV-LTR

1.1.27 Activated c-src Expression under the MMTV-LTR (I)

1.1.28 src Expression under the MMTV-LTR (II)

1.1.29 Polyoma Middle t Expression under the MMTV-LTR

1.1.30 Overexpression of Parathyroid Hormone-Related Protein or Parathyroid Hormone Impairs Branching Morphogenesis

1.1.31 Synergism of TGF-alpha and c-myc in Mammary and Salivary Tumorigenesis

1.1.32 Deficiency of p53 Accelerates Mammary Tumorigenesis in Wnt-1 Transgenic Mice

1.1.33 Dominant-negative Interference of the TGF-b Type II Receptor in Mammary Gland Epithelium

1.1.34 Fibroblast Growth Factors in Mammary Gland Epithelium

1.1.35 Active Signaling by Neu in Transgenic Mice

1.1.36 Neu Differentiation Factor (NDF) Causes Apoptosis

1.1.37 Overexpression of MDM2 in mmary Cells Causes Polyploidy and Tumors

1.1.38 Kinase-deficient Transforming Growth Factor-beta Type II Receptor

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1.2. Cell Cycle Proteins

1.2.1 SV40 T-antigen Expression under the WAP Promoter

1.2.2 SV40 T-antigen Expression under the Prostate C3 Promoter

1.2.3 T-antigen Expression in the Salivary Gland under the tet Responsive System

1.2.4 Expression of Wild Type and Mutant p53 (R-L 172)

1.2.5 Mutant p53 (R-H 172) under the WAP gene promoter

1.2.6 cyclin A Expression under the BLG Promoter

1.2.7 cyclin E Expression under the BLG Promoter

1.2.8 cdk2 Expression under the BLG Promoter

1.2.9 cyclin D1 Expression under the MMTV-LTR

1.2.10 cyclin E Expression under the MMTV-LTR

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1.3. Matrix Proteinases

1.3.1 Stromelysin Expression under the WAP Promoter

1.3.2 Stromelysin Expression under the MMTV-LTR

1.3.3 TIMP-1 Overexpression Alters lobulo-alveolar Development

1.3.4 Matrilysin Expression under MMTV-LTR

1.3.5 b1-integrin Expression under MMTV promotor

1.3.5 The Stromal Proteinase MMP3/Stromelysin-1 Promotes Mammary Carcinogenesis

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1.4. Apoptosis Genes

1.4.1 bcl-2 Expression under the WAP Promoter


1.5. Viral Oncoproteins

1.5.1 Polyomavirus large T antigen expression under control of the MMVT-LTR

1.5.2 Polyoma Middle t Expression under the MMTV-LTR

1.5.3 Polyma Virus Middle T Mutants

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1.6. Double Transgenic Mice

1.6.1 Expression of cyclinA and cdk2

1.6.2 Synergism of TGF-alpha and c-myc in Mammary and Salivary Tumorigenesis

1.6.3 SV40T-ag Expression in the tet Responsive System

1.6.4 MMTV-TGFb1/MMTV-TGFa

1.6.5 WAP_p53 (R-H)/WAP-TGFalpha

1.6.6 Wap_p53 (R-H)/WAP-des-IGF1

1.6.7 WAP-p53 (R-H)/MMTV-neu


1.7. Null Mice Carrying Transgenes

1.7.1 MMTV/c-myc in a p53 -/- Background

1.7.2 Deficiency of p53 Accelerates Mammary Tumorigenesis in Wnt-1 Transgenic Mice

1.7.3 Polyoma T Oncogene in a c-src Null Background

1.7.4 SV40 Tag expression in the absence of p53

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1.8. Tetracycline Inducible System

1.8.1 HCMV-tTA

1.8.2 MMTV-tTA

1.8.3 tTA Expression in the CaM kinase Promoter

1.8.4 SV40Tantigen under Control of the tetop

1.8.5 Mice Carrying the Autoregulatory tet Responive System

1.8.6 T-antigen Expression in the Salivary Gland under the tet Responsive System

1.8.7 Alpha-lactalbumin under dox Control

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1.9. Cre Expressing Mice

1.9.1 WAP-Cre and MMTV-Cre Transgenic Mice

1.9.2 BLG-Cre Transgenic Mice


1.10. Others

1.10.1 Overexpression of Cell Surface b1,4-galactosyltransferase under the MT Promoter

1.10.2 Overexpression of Parathyroid Hormone-related Protein or Parathyroid Hormone Impairs Branching Morphogenesis


1.11. Transgenic mice with the MMTV-LTR


1.12. Transgenic mice with the WAP gene promoter


1.13. Transgenic mice with the -lactoglobulin promoter

1.13.1 Alpha-lactalbumin under dox Control

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